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Therefore, dietary supplementation is required to maintain adequate biological levels [151]

PubMed Masliah, E., & Dez-Tejedor, E

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Anson M, Zhao SS, Austin P, Ibarburu GH, Malik RA, Alam U

Another study on cats demonstrated that subcutaneous DSIP injection significantly increased deep slow-wave sleep activity

This is referred to as tolerance. In addiction or misuse, tolerance also occurs and as a result, the person will tend to increase the dose or frequency